GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs7692995 | 1 | rs4642247 | chr4:17957158 | DCAF16 | chr4:17802280-17812381:- | -0.2 | -4.37 | 1.51E-5 | Height |
| THCA | cis | rs10862219 | 1 | rs4643132 | chr12:81458555 | ACSS3 | chr12:81471809-81649582:+ | 0.22 | 4.67 | 4.01E-6 | Neuroticism |
| THCA | cis | rs12908161 | 1 | rs4643294 | chr15:85250253 | GOLGA6L5 | chr15:85047738-85060078:- | -0.15 | -3.86 | 0.000128 | Schizophrenia |
| THCA | cis | rs12908161 | 1 | rs4643294 | chr15:85250253 | LOC388152 | chr15:84867600-84898920:- | -0.48 | -8.09 | 5.01E-15 | Schizophrenia |
| THCA | cis | rs12908161 | 1 | rs4643294 | chr15:85250253 | NMB | chr15:85198362-85201802:- | 0.37 | 7.72 | 6.74E-14 | Schizophrenia |
| THCA | cis | rs7606754 | 1 | rs4643535 | chr2:228133809 | MFF | chr2:228189978-228222547:+ | -0.23 | -5.03 | 7.03E-7 | Corneal structure |
| THCA | cis | rs5743030 | 1 | rs4643578 | chr2:190526684 | ASNSD1 | chr2:190526125-190535556:+ | -0.76 | -8.25 | 1.55E-15 | Subcutaneous adipose tissue |
| THCA | cis | rs2274273 | 1 | rs4644 | chr14:55604935 | KIAA0831 | chr14:55833110-55878576:- | -0.12 | -3.36 | 0.000854 | Protein biomarker |
| THCA | cis | rs6982751 | 1 | rs4645525 | chr8:10816174 | CTSB | chr8:11700036-11725646:- | 0.22 | 3.46 | 0.000578 | Asthma and hay fever |
| THCA | cis | rs10242455 | 1 | rs4646457 | chr7:99245080 | ATP5J2 | chr7:99055785-99063808:- | -0.18 | -3.82 | 0.000152 | Blood metabolite levels |
| THCA | cis | rs10242455 | 1 | rs4646457 | chr7:99245080 | ZNF655 | chr7:99156045-99174074:+ | -0.17 | -3.51 | 0.000492 | Blood metabolite levels |
| THCA | cis | rs9333029 | 1 | rs4646492 | chr1:47281183 | NSUN4 | chr1:46806390-46830690:+ | 0.22 | 3.38 | 0.000772 | Blood metabolite levels |
| THCA | cis | rs703842 | 1 | rs4646536 | chr12:58157988 | FAM119B | chr12:58166383-58176323:+ | 0.38 | 10.71 | 4.0E-24 | Multiple sclerosis |
| THCA | cis | rs703842 | 1 | rs4646536 | chr12:58157988 | METTL1 | chr12:58162352-58165914:- | -0.17 | -4.35 | 1.69E-5 | Multiple sclerosis |
| THCA | cis | rs703842 | 1 | rs4646536 | chr12:58157988 | TSFM | chr12:58176536-58191367:+ | -0.54 | -18.57 | 2.47E-58 | Multiple sclerosis |